Carolyn Lou

Automated Detection of Paramagnetic Rims in Multiple Sclerosis Lesions on 3T Susceptibility-based MR Imaging

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Carolyn Lou, Biostatistics

I am a doctoral candidate in biostatistics at the University of Pennsylvania as a part of the Penn Statistical Imaging and Visualization Endeavor (PennSIVE) Center. My research interests include statistical and computational methods for the analysis of neuroimaging data and clinical trials.

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BioRxiv Link to Paper

Authors

 

C Lou1,  P Sati2, Absinta3, K Clark1, J Dworkin4, A Valcarcel1, M Schindler5, D Reich6, E Sweeny7, R Shinohara1

  1. Penn Statistics in Imaging and Visualization Endeavor (PennSIVE) Center, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.
  2. Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  3. Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  4. Department of Psychiatry, Columbia University Medical Center, New York, New York, USA.
  5. Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
  6. Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
  7. Department of Population Health Sciences, Weill Cornell Medicine, New York, New York, USA. 

Abstract

The presence of a paramagnetic rim around a white matter lesion has recently been shown to be a hallmark of a particular pathological type of multiple sclerosis (MS) lesion. Increased prevalence of these paramagnetic rim lesions (PRLs) is associated with a more severe disease course, but manual identification of PRLs is time-consuming. We present a method to automatically detect PRLs on 3T T2*-phase images. T1-weighted, T2-FLAIR, and T2*-phase MRI of the brain were collected at 3T for 19 subjects with MS. Images were then processed with automated lesion segmentation, lesion labelling, and lesion-level radiomic feature extraction. A total of 877 lesions were identified, 118 (13%) of which contained a paramagnetic rim. We fit a random forest classification model on a training set and assessed our ability to classify PRL lesions on a test set. The number of PRLs per subject identified via our automated lesion labelling method was highly correlated with the gold standard count of PRLs per subject, r = 0.91 (95% CI [0.79, 0.97]). The classification algorithm achieved an area under the curve of 0.80 (95% CI [0.67, 0.86]).

Keywords

neuroimaging; radiomic image analysis; machine learning;

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