Dr. Mumford is renowned for her research on modifiable dietary and lifestyle factors affecting reproductive health, which has informed guidelines for women, men, and couples. Her work uses couples-based approaches with participants recruited before conception, combining large datasets to examine dietary and lifestyle factors.

In the IDEAL Fertility Study, she uses innovative wearable technology to address exposure misclassification and the timing of physical activity and sleep during infertility treatment, yielding more translatable results due to the widespread use of these devices. Her interdisciplinary training in nutritional and reproductive epidemiology and biostatistics provides unique expertise in designing and analyzing population-based studies to improve health across the life course.

She also is MPI for the Penn-CHOP ECHO (Environmental influences on Child Health Outcomes) cohort, which aims to understand the microenvironmental and macroenvironmental factors that influence maternal and child health.